Mythbusters is a great thing that we would all love to experience again in another medium, but that just wasn't going to happen. It's hard to even point to an existing good game that has the mechanics that you'd want from a Mythbusters. They could have gone Factorio, or an Infinifactory, but a goal of "maximize this" or "build this intended output" still doesn't capture the scientific intent of extracting some tiny nugget of truth from a cold unfeeling universe. Straitjacketing the whole process into something scripted, or throwing a sandbox at the player and walking away, are about the only two approaches that a game could do.