Sure. You can fix frame rate drops, play with any controller you want, easier to play with mods, save states, speedup when replaying a game, easier to record video or stream. If you're playing a 3d game you can run in higher resolution with better anti aliasing and anisotropic filtering. For a 2d game sometimes one of the upscaling filters will look good. You can use CRT filter if you want and you don't have a CRT TV. You could do it on Steam Deck and cloud sync your saves with your PC, and even your phone (especially for turn based games)