The video game is based on the Cyberpunk Tabletop/pen and paper RPG. Think like D&D but in the world of cyberpunk, hacking instead of spells, etc. I'm not an expert (still trying to get a real life game together tbh) but I don't think any of the TTRPG games have focused much outside of night city. You can of course put your game anywhere, but the premade stuff is all in and around night city.

There's ton of supplement on the original game for europe, moscou there's so many possibilities, the cyberpunk world is very interesting even outside of nightcity, i embrace that take as an OG cp2020 game master.

I wouldn’t mind a different city, or multiple cities.

I was gonna make a joke about how it's not gonna come out until 2077 but I couldn't make it work.

It's possible that I'm also hoping that the sequel won't take a decade to release if they're able to reuse most of Night City from the fist game.