Only one item can be delivered at a time. It can’t weigh more than 5 pounds. It can’t be too big. It can’t be something breakable, since the drone drops it from 12 feet. The drones can’t fly when it is too hot or too windy or too rainy.
You need to be home to put out the landing target and to make sure that a porch pirate doesn’t make off with your item or that it doesn’t roll into the street (which happened once to Lord and Silverman). But your car can’t be in the driveway. Letting the drone land in the backyard would avoid some of these problems, but not if there are trees.
Amazon has also warned customers that drone delivery is unavailable during periods of high demand for drone delivery.
They're working on next generation air traffic control, that is automated and also can handle drones whizzing around next to flying cars, but developing that isn't fast or cheap or deploy and will need extra equipment on the ground and in the cockpit.
...and that's still just for the drones.