I have always wanted to try printing larger, using a bigger nozzle - just got around to swapping to a .6mm in my MK3S+. Printed a gift for a childhood friend. 300% size. Took just under 10 hrs. With the slicer settings on .4mm it was over 17hrs.
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I also use .6 as my standard nozzle. Since the stuff I print is usually custom brackets and cases, a bigger nozzle would be even more ideal. The problem is my stock heating can't keep up with anything larger than a .6
What printer and hot end?
It's an ender 3 pro with the stock hot end, but it's also running klipper and prints at 60mm/s
I have the same setup and with a bigger nozzle I found it useful to use auto speed and max volumetric flow, rather than speed. I found the hotend reaches its flow capacity before speed becomes an issue.
What slicer are you using? I'm using Cura and I vaguely remember that being the reason why I didn't do that.
I've been using super slicer, but it's a fork of prusa slicer and I'm pretty sure the auto speed feature is a prusa slicer thing.