The obvious answer is Pathologic. You play as one of three possible characters in a black plague-infested town in the russian steppe, trying to help people and survive.

As days go by, the situation worsens and, in order to survive, you are forced to make very hard decisions. Can you spare the food for the others? Will you rob someone of their medicines? Will you risk going to the most dangerous parts of the city, where the stench of infection permeates the air?

I'll quote The Nocturnal Rambler's review of the game, which is one of my favourite video game reviewers:

Making it to the end of a day is a genuine accomplishment in this game, considering all the work you have to do to stay alive, and that the game really doesn't care if you live or die. It won't hold your hand to make sure you get through to the end; it's entirely possible to make it through 10 days and then back yourself into a corner where you have absolutely no hope of survival, short of loading a save from a few (in-game) days ago. Or perhaps to save yourself the agony of replaying several hours of the game, you end up in terrifying, desperate scenarios where you have to sell your only weapon for a few scraps of bread, or murder a child for the medicine he's carrying while you're about to die from infection. That's true horror right there.

It's not an easy game and it's not a good game, even. It's old and dated and janky, but it's also full of charm and personality. I wouldn't say it's a game meant to be played, as much as it is an experience worth going through. You won't have fun playing the game. Even if you can overlook its pain points, it's an objectively oppressive game that will make you feel miserable from beginning to end, and increasingly so. I wouldn't say it's for everyone, and I don't mean that in an elitist way. Some people simply won't stand this much bleakness during the time they are supposedly spending to find entertainment.