I know I'm playing this very late. Anyway I was pretty deep in a certain cave (1,200 ft) with a leviathan and I was taking care of some stowaways on the hull of the sub. Thinking it'd be more fun to use the cannon instead of the knife, I blasted away. A couple seconds later I watched in horror as all my lockers clip through the cyclops and sink to the bottom.

The leviathan would attack on every pass and the lockers would either get blasted away even farther apart or respawn entirely. In the end, they all despawned... I was working on building a base with a platform shield over top so I could collect everything again, but it all went poof.

Luckily, I saved within the last 30 minutes... But if I hadn't have, I would have lost all the resources (about 40+ lockers full) and I probably would have just quit the game lol.