I almost exclusively play for A20 heart kills. I play all 4 classes but in a "whichever I feel like today" way. I tried rotating between the characters for a while and really didn't enjoy playing silent or watcher while in the wrong mood for those classes.

My favorite deck in recent memory was probably a silent discard combo with Grand Finale as the only damage-dealing card in the deck. My favorite archetype in general is probably ice defect. A good all-you-can-eat ironclad run is great too.

I don't think I agree that STS is especially well balanced - some regular hallway combats do irrationally more damage on average even to players much better than me (for example, floor one jaw worms or any act 3 darklings). In general, the game could be quite a bit harder on A20 and still be fun for players who want a challenge. It's also weird to me that A1 makes the game easier compared to A0. Between the classes, there is a class which is clearly stronger than the others. However I also don't think this is a bad thing. Imbalances create more opportunities for new experiences, and for different kinds of players to have different kinds of fun. And that certainly agrees with "infinite replayability." I'm sure in 5 years' time I will still be seeing interactions I've never seen before.