I agree that it depends on your use case. If you're an artist or illustrator you can make do with a number of alternatives and just go elsewhere for photo editing, and if you're just doing basic adjustments to photos rather than detailed edits you can figure it out as well.

Photohop is harder to bypass if you're a jack-of-all-trades user mostly doing image editing but also dabbling in the other options from time to time. That's not to say you can't do it if you try, but it's going to be less convenient and add friction to your workflow.