I've switched a few months ago mostly for gaming, and here are few tips and issues I ran into, in case you run into them too.

Not sure what distro you are using, but I've run mostly into issues when trying to get NVIDIA and Proton working on Fedora. Just getting the drivers to work took a few tries, and I never managed to get stuff like cutscenes to work properly.

However, I then switched to Nobara (I suppose PopOS may also work), and the experience was wastly better, with everything working out of the box (I did switch to KDE Plasma on X11, since Wayland kept freezing on me).

I'm not sure what of the many changes Nobara does helped solve my issues, but I guess it may be related to it including Proton GE by default, which I recommend getting, and a slightly streamlined installation of NVIDIA drivers.

I also recommend checking out Lutris, instead of using Wine directly. However, I never really managed to get it working, aside from WoW, so your mileage may wary. But I have most of my games on Steam, where everything is working out of the box, so it wasn't that much of na issue. I only sometimes have to switch Proton version (by right clicking the game - properties - Force a specific version of compatibility tool).