Functionally speaking, I don't see this as a significant issue.

JPEG quality settings can run a pretty wide gamut, and obviously wouldn't be immediately apparent without viewing the file and analyzing the metadata. But if we're looking at metadata, JPEG XL reports that stuff, too.

Of course, the metadata might only report the most recent conversion, but that's still a problem with all image formats, where conversion between GIF/PNG/JPG, or even edits to JPGs, would likely create lots of artifacts even if the last step happens to be lossless.

You're right that we should ensure that the metadata does accurately describe whether an image has ever been encoded in a lossy manner, though. It's especially important for things like medical scans where every pixel matters, and needs to be trusted as coming from the sensor rather than an artifact of the encoding process, to eliminate some types of error. That's why I'm hopeful that a full JXL based workflow for those images will preserve the details when necessary, and give fewer opportunities for that type of silent/unknown loss of data to occur.