We make sure the kids use the restroom at each stop, we don't give them many liquids, and distract them w/ tablets and audiobooks. But honestly, half the time we need to stop in the middle of nowhere because it's an "emergency" and they can't make it to the next stop (to be fair, where we go, stops are about every 20-50 miles), so they'll pee on the side of the road (we keep baby wipes and hand sanitizer handy).

If I could time it perfectly, an EV could potentially work. But with so much space between reasonable stops and a high chance for "emergencies," it would probably add another hour or two to the total trip time if we had to wait to recharge, and that's assuming we can reliably find available fast chargers (I hear they're often broken/occupied).