My cat has a fungal infection in his brain and requires one pill twice a day. Been doing this for sevenish years. He's the only cat I've ever had, so take this with a grain of salt, but I just get him on my chest and pet him until he starts purring. Then I use a finger to open his mouth and push the pill to the back of his throat, and immediately go back to petting him. He swallows it, and sometimes gags for a second. But, I do it really quickly, and usually it's over quick enough that he doesn't even stop purring. YMMV