I haven't really used Nginx, but from a quick look nginx seems to be restarting everytime as it attempts to delete some proxy configuration (?), but fails to do so with code "ENOENT" which just means that such file or directory does not exist.

I also found this issue in the nginx github repo: https://github.com/NginxProxyManager/nginx-proxy-manager/issues/3497

According to the discussion in that issue, it seems like nginx is the one causing the problems. Consider downgrading the nginx container image to what it was before if it updated itself.

It also could be something being corrupted, so you might need to dig some more into this matter.

People also recommend switching to other reverse proxies like caddy and traefik. I also recommend it, you might as well take this as a opportunity to use something better. I personally recommend Caddy, as it is very simple to configure and very convenient. It handles HTTPS and all that boring stuff for you. Iirc it also has a cloudflare module, so you can just follow the guide in the documentations to let Caddy automatically renew certs for you via access tokens.