Playing as a Ghoul (with customizable design and even skin texture) is an endgame experience, as the related quest only starts at level 50. Ghouls will have 'dozens of alternate ways' to specialize their character, according to the developers.

To begin with, they are not only immune to radiation; it actually heals them. If your character is hurt, standing on top of some radioactive material will start healing them. Moreover, once fully healed, the excess radiation will build up into a new resource called Glow. Depending on how the player character is specialized, Glow can provide various effects. Ghouls can also utilize 32 exclusive perk cards on top of those already available for human characters, providing great variety when it comes to character progression.