Well, the best thing that happened to me was meeting my girlfriend. Just happened a month ago, but we already feel like we're going to spend the rest of our lives together and this is after me not dating at all for almost fifteen years.
So, the second best thing has to be several months ago when my family caught on to the fact that I was depressed and overwhelmed with clutter from stuff I was hoarding because I felt too guilty about throwing things away. They helped me sort through it all so it wasn't so overwhelming. My living space is nice and tidy now and that's what allowed me the confidence to go meet a partner who is perfect for me in almost every way.