Try Bottles! It's a well designed app that allows you to create and manage Wine environments. It's released as a Flatpak, so it benefits from sandboxing (especially if you harden things with a tool like Flatseal). https://usebottles.com
No, not by deafult (some windows viruses are compatible with wine)
You could create systemd services to control wine for each app you want to run, that way you can use systemd's sandboxing.
You could try Sandwine https://github.com/hartwork/sandwine not used personally but looks like it has enough restrictions built in.
Linux
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Linux is a family of open source Unix-like operating systems based on the Linux kernel, an operating system kernel first released on September 17, 1991 by Linus Torvalds. Linux is typically packaged in a Linux distribution (or distro for short).
Distributions include the Linux kernel and supporting system software and libraries, many of which are provided by the GNU Project. Many Linux distributions use the word "Linux" in their name, but the Free Software Foundation uses the name GNU/Linux to emphasize the importance of GNU software, causing some controversy.
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