Tried couple of them but still came back to Obsidian with remotely-save (for me it's S3 but doesn't matter) for last 2 years. The sheer simplicity plus the fact that I don't have to synchronize every second (it's only my notes, no collaboration) beats every other solution.
If you'd like an alternative, see Trillium Next (community driven fork) but despite the fact that it's great it doesn't beat my current setup (yet π)
Affine is good too, but it is a bit more complicated with the benefit of more features.
I really like that dev is ambitious here and have my fingers crossed π€πΌ
The more self hosted alternatives we have the better, maybe someday I'll need one π