They only list support for Windows and MacOS on their site. The answer is almost certainly no, it doesn't work with Linux. People may reverse engineer it like they did with the Stream Deck or GoXLR devices, but don't hold your breath. Your best alternative would be something like this: https://drop.com/buy/megalodon-doio-hot-swappable-rgb-30-keyboard?defaultSelectionIds=970727
EDIT: Or, you could build your own without the need of a raspberry pi using something like this: https://www.instructables.com/STREAM-DECK-KILLER-and-OpenSource/
I've been able to return some games based on news that they will be adding kernel-level anti-cheat. I'm glad Valve is doing this right.