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Microsoft won’t let you close OneDrive on Windows until you explain yourself
(www.theverge.com)
This is a most excellent place for technology news and articles.
You could also open its executable with a hex editor and mangle its header. That'd sure keep it from running, regardless of what anyone else on the computer fiddled with. Or being "helpfully" relaunched by the system, despite your efforts.
Not sure if Windows Update would notice and overwrite the file. Maybe after you do this, mark it read only.