I know its memes and not much depth is expected, but I think its slightly more.
As in, Pharmacist is a socially acceptable profession. Xanax is a socially acceptable pharmaceutical. It is socially acceptable for a patient to take this medication. However, this particular person is planning to abuse the drug, while still maintaining social acceptability, and the pharmacist knows this too, and is giving a wink and a nod they are aware of it.
The joke being "we're not dirty drug dealers and users, but really, for this case, we are, and we're getting away with it being socially acceptable."
You know your industry better than I do, but my industry-agnostic answer would be: "Yes, absolutely apply if it moves your career forward". Even horrible bosses/departments can be useful as stepping stones. Many times these are open and others are avoiding them because the environment/boss sucks. If you can do a year in that department/boss as a springboard to a higher position elsewhere, I typically think its worth it.