"Superman!"

The sequence at the end of the Six Feet Under finale set to Sia's Breathe Me absolutely gutted 2005 me.

This scene from Interstellar. I'm thoroughly convinced that it is impossible to get through this movie without getting teary-eyed at least once.

The last part of AI (2001)

"A toast to my big brother George, the richest man in town."

Alternatively:

"You are who you choose to be."

"Superman."

I cry quite easily, so a small sample of films that have made my eyes misty are:

The Remarkable Life of Ibelin
Bridge to Terabithia
A Monster Calls

Maes Hughes' big action moment in Full Metal Alchemist - either version.

Alternatively, the scene this music https://youtu.be/EL7e5XrzanA goes to (Ep 5 of Cowboy Bebop) - far more of a tear jerker for me than the final episode.

When Homer drives his mom to the middle of nowhere so she could meet up with some friends to escape the police and he just stays there even even after she’s long gone long enough for day to turn into night.

Star Trek DS9’s “The Visitor”

The intro to the game stray

General Waverly walks out in uniform to find his old unit waiting for him. (“White Christmas”)

The last scene of the last episode of Six Feet Under.

The episode "The Sign" of Bluey, the end.

The movie 'About Time'. The ending tore me up.

My obvious pick: "It's a terrible day for rain."

My niche pick: Patch Adams. The scene where he considers || jumping off the cliff ||

My IDGAF what you think pick: Avengers Endgame. "Hey, Pep" and "You can rest now."

Cinema Paradiso. Wonderful Italian film about a boy’s relationship with an elder in the town as he mentally escapes war torn Sicily. Just wholesome and hits hard. It’s a beautiful story and the soundtrack by Ennio Morricone, ohhhh so good.

Another one is the movie 'The Fountain' which is played excellently by Hugh Jackman.

I found the entire concept, but especially the "happy ending" of Paulie to be tragic and extremely depressing to me.

My mother loved Beaches and Steel Magnolias but they always ruined my day. Then my mother died of cancer and they crossed into the unwatchable list.

Les Mis

for example: https://m.youtube.com/watch?v=ulJXiB5i_q0

The ending of that Scrubs episode with Brendan Fraser https://m.youtube.com/watch?v=e__1KU7lg-4

The ending of Jurassic Bark https://m.youtube.com/watch?v=0WBbKSFhw9A

Watching the music video for My Heart Will Go On

The ending of this Cold Case episode https://m.youtube.com/watch?v=jMc_RyGBjBE

The ending of Pan's Labyrinth

The music video for Hozier's Take Me To Church

The liberation of a concentration camp in Band Of Brothers

So I don't get to the cinema much, but I got to see The Muppets when it came out (over a decade ago, good grief), and Kermit singing Pictures In My Head totally broke me.

Dunno whether it will work for anyone else, but like many of a certain age, I grew up with the original Muppet Show on TV and it hit too damn hard.

Inside Out

Not a movie, but has anybody here seen the anime Anohana. If you can watch that and not cry in every episode, you're a bonafide sociopath.

The sinking of the Going Merry. Oda made me cry for a boat, and I'm not even joking.

The scene at the end of About Time between the father and son. I won't describe it, since I don't want to ruin it for anyone.

Toy Story 4. The scene where Woody says goodbye to the rest of the toys and goes off on his new adventure with Bo Peep. Gets me every time.

The original Toy Story was the first movie I remember seeing in a theatre so maybe there's some nostalgia contributing to that.