The Bob's Burgers episode "The Amazing Rudy" (season 14, episode 2).

Regular-sized Rudy goes out to eat with his divorced parents and their new significant others. It goes horribly wrong and he runs away to the Belchers'. I tear up a little bit even thinking of it because it isn't played for laughs. I really feel for Rudy, just trying his hardest and putting way too much pressure on himself, and the way Louise steps up for her best friend is just so sweet.

The first minutes of Up.

"where do you think we are?"

The context is what makes this powerful. The buildup, the misdirection, the reveal.

This was Scrubs at its best. McGinley should have won an Emmy right there.

Opening for “Up” not in the top comments?

The Last Emperor - end scene

Bicentennial Man - end scene

Avalon 1990 - end scene

The Notebook - end scene

The Danish Girl - end scene

Dancer in the Dark - end scene

Star wars; the last Jedi

The Holdo maneuver.

Miguel from Coco singning "Remember me" with Coco.

The Iron Giant

The scene in Interstellar when he returns from the time dilation to watch like 40 years of updates he missed from his kids.

The original Fresh Prince when Will is desperately trying to convince himself he doesn't need his dad. Every time.

"little soldier boy" episode from Avatar: the last Airbender. Every time.

The last 15 minutes of "The Return of The King," starting with, "My friends... You bow to no one."

Every. Damn. Time.

Grave of the fireflies... Sometimes the trailer is already enough... F*** can't even rewatch the thing...

A few episodes of Futurama. You can guess which ones.

Been a while but probably the opening sequence of Up

"I have been, and always shall be, your friend."

-Spock, Star Trek II: The Wrath of Khan

First season of After Life by Ricky Gervais.

The scene after where Gervais' character realizes fully what he has done, especially to himself long term, is soul crushing. The i did the right thing, but for all of the right and wrong reasons look on his face is haunting. I think it is the 2nd episode.

A lot of the episodes open with him watching his wife telling him to enjoy life. Her sitting on the hospital bed, on her final days because of cancer.

What dreams may come, 1998 movie with Robin Williams.

Ibelin. Saw it in the cinema when it first came out, seemed like everybody in the audience was crying.

(It's about a kid with a degenerative disease who connected with people through an MMO.)

ANY time any dog dies.

Buffy The Vampire Slayer, “The Body”.

Mom? Mom! Mommy?

The dad doing one last goofy march while his son watches, in Life is beautiful (1997)

Ending of the Sixth Sense.

"Grandma says you asked her a question. She says to tell you the answer is 'every day', what was the question, momma?"

"Did I make you proud?"

Grave of fireflies, of course

S1E3 of Last of Us - "Long, Long Time." Happy and sad tears galore.

The opening scene of Hackers (1995). Poor kid can't use a touch tone telephone or computer until his 18th birthday.

That's like taking away Mozart's piano.

Birdman (with Michael Keaton) - nothing in the actual movie but the absolute soul crushing sadness when I realized that they weren't making a Harvey Birdman Attorney at Law movie.

Buffy the TV show, when she discovers her mother's dead body.

"Mom? MOM! ... Mommy?" Tears

Oh the scene/secquence? From Tim Burton's "Big Fish" when he gets the dad back in the water. That was so wholesome but so sad at the same time.

A lot of seens in Logan with Professor X. His mental decline was a gut punch because I was watching my grandfather go through the same thing at the same time. His portrayal was spot on.

Happy with Stark's daughter on the porch talking about cheeseburgers. Such a small moment, but so genuine feeling.

The ending of Watership Down. Can't even think about without getting misty.

Spock: “I have been and always shall be your friend” [dies]

Kirk: “No….”

Into the wild when he discovers that human existence isn't meant to be lived in isolation and then dies a few days later in total isolation.

The end of Saving Private Ryan always gets me as well.

The last part of AI (2001)